Bioinformatics and Computational biology

Modern techniques for analyzing biological specimens produce large amounts of data describing gene expression, genome sequences, molecular structures, and molecular interactions. Researchers in the field of bioinformatics develop methods and tools to manage and make meaning of this data. Computational biologists use this data to better understand living systems, while researchers in translational bioinformatics apply these insights to efforts to improve human health.

• University of Kentucky Markey Cancer Center - Cancer Center Support Grant
• CAREER: Linking Structure, Stability and Protection in Protamine Packaged DNA
• Supplement: Cost Extension - Kentucky Center for Clinical and Translational Science
• CAREER: Developing Biochemoinformatics Tools for Large-Scale Metabolomics Applications
• Lung cancer in Appalachian Kentucky: Deciphering genetic influences

• • journal article | 2021
  • McKinnon LM, Miller JB, Whiting MF, Kauwe JSK, Ridge PG
  • A comprehensive analysis of the phylogenetic signal in ramp sequences in 211 vertebrates
  • Sci Rep
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• • journal article | 2020
  • Ellingson SR, Davis B, Allen J
  • Machine learning and ligand binding predictions: A review of data, methods, and obstacles
  • Biochimica et biophysica acta. General subjects
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  • journal article | 2020
  • Jin H, Mitchell JM, Moseley HNB
  • Atom Identifiers Generated by a Neighborhood-Specific Graph Coloring Method Enable Compound Harmonization across Metabolic Databases
  • Metabolites
• •  
  • journal article | 2020
  • Yao S, Moseley HNB
  • A chemical interpretation of protein electron density maps in the worldwide protein data bank
  • PloS one
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  • journal article | 2020
  • Hinderer EW, Moseley HNB
  • GOcats: A tool for categorizing Gene Ontology into subgraphs of user-defined concepts
  • PloS one
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  • journal article | 2020
  • Powell CD, Kirchoff DC, DeRouchey JE, Moseley HNB
  • Entropy based analysis of vertebrate sperm protamines sequences: evidence of potential dityrosine and cysteine-tyrosine cross-linking in sperm protamines
  • BMC genomics
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  • journal article | 2020
  • Jin H, Moseley HNB
  • Robust Moiety Model Selection Using Mass Spectrometry Measured Isotopologues
  • Metabolites
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  • journal article | 2020
  • Mitchell JM, Flight RM, Moseley HNB
  • Deriving Lipid Classification Based on Molecular Formulas
  • Metabolites
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  • journal article | 2020
  • Liu S, Liu J, Xie Y, Zhai T, Hinderer EW, Stromberg AJ, Vanderford NL, Kolesar JM, Moseley HNB, Chen L, Liu C, Wang C
  • MEScan: a powerful statistical framework for Genome-Scale mutual exclusivity analysis of cancer mutations
  • Bioinformatics (Oxford, England)
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  • journal article | 2020
  • Zhong Y, Mohan K, Liu J, Al-Attar A, Lin P, Flight RM, Sun Q, Warmoes MO, Deshpande RR, Liu H, Jung KS, Mitov MI, Lin N, Butterfield DA, Lu S, Liu J, Moseley HNB, Fan TWM, Kleinman ME, Wang QJ
  • Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium
  • Biochimica et biophysica acta. Molecular basis of disease