With the passing of the 21st Century Cures Act and aligning with NIH/PHS Policy, the USDA is no longer requiring annual review of IACUC protocols. Principal investigators (PIs) will not submit information for annual review and approval in the Cayuse system. The OAV-IACUC office will continue to check training and University Health Service clearance on a yearly basis and reach out to individuals who need to complete/renew these items. PIs who previously reported animal numbers via the progress report will also be contacted to collect this information (e.g., agriculture, biology, wildlife, core protocols). Please report any unanticipated adverse events and noncompliance directly to your clinical veterinarian (DLAR) or the Attending Veterinarian. This update does not affect three-year de novo reviews. IACUCs are still required to conduct a complete review of animal activities every three years. Any changes to approved protocol activities must be submitted as an amendment.