2016 KNI Clinical-Translation Research Symposium Abstracts

• Pioglitazone Improves Functional Neuroprotection Following Spinal Cord Injury
• Neuroprotective Effects of Inhibition of α5β1  Integrin Following Experimental Stroke: A Dual Centre Pre-Clinical Study
• Leukemia Inhibitory Factor Confers Neuroprotection During Ischemic Stroke Through Enhanced LIFR Expression and Membrane Localization
• Peripheral Macrophages are Viable Therapeutic Targets in Traumatic Brain Injury

• PERK Inhibition in rTg4510 Mouse Model of Tauopathy Rescues Impairment Through elF2α-independent pathway
• Translating CD33 Genetics to an Alzheimer's Disease Pharmacologic Agent
• Therapeutic Development of a Novel siRNA Compound Targeting Alpha-Synuclein
• A Phase I, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study of AT-001 Yeast Selenium for the Prevention of Alzheimer's

• Diabetes and the Brain: A Hidden Trigger of Brain White Matter Disease
• Vascular Dementia and Angiotensin Signaling
• Observing Changes in Cerebral Blood Flow and Hippocampal Metabolites by Magnetic Resonance After a Closed Head Traumatic Brain Injury in Mice
• Factors Associated with Moyamoya Syndrome in the Kentucky Regional Population

• Molecular and Electrophyisological Characterization of Neuropeptide Y Y1 Receptor-expressing Neurons in the Substantia Gelatinosa of the Spinal Cord
• Is Chronic Pain an Initiator of Tauopathy?
• Outcomes Following the Conservative Management of Patients with Non-radicular Peripheral Neuropathic Pain
• Visual Field Deficits in Patients with Headache Disorders: A 2-year Prospective Cohort Study

• Insulin-like Growth Factor-1 Overexpression Mediates Regional Alterations to the mTOR Signaling Pathway in the Hippocampus Following TBI
• mTOR Inhibition After Controlled Cortical Impact Alters Hilar Interneuron Excitability
• Synaptic Mitochondria Sustain More Damage than Non-Synaptic Mitochondria Following Traumatic Brain Injury and are Protected by Cyclosporine A
• Brain Injury Signaling Events After Expression of Mitochondria Associated microRNA
• Phenelzine Administration following Traumatic Brain Injury Improves Mitochondrial FUnction and Reduces Lipid Peroxidation and Cytoskeletal Degradation
• Effects of Controlled Cortical Impact Brain Injury on Cell Loss and Neurogenesis in the Mouse Dentate Gyrus
• Activation of PERK in Controlled Cortical Impact Model of Traumatic Brain Injury
• IL-1β Levels After TBI can be Inhibited with the Therapeutic MW151 without Affecting Microglial Physiological Responses

• Elucidating Subtypes and Risk Factors of Brain Arteriosclerosis
• Intra-arterial IL-1α is Well Tolerated and Neuroprotective After Experimental Ischemic Stroke
• Amylin Vasculopathy, a Novel Mechanism of Cerebrovascular Injury and Neurologic Deficits in Diabetes
• Early Non-white Matter Changes in Cerebrovascular Integrity in Mouse Brain Following Bilateral Carotid Artery Stenosis
• Gait Abnormalities, Impaired Balance and Brain White Matter Hyperintensities in a Rat Model of Late-Onset Type-2 Diabetes
• Intra-arterial Pharmacotherapy Administration Following Experimental Stroke Improves Neuronal Survival and Functional Outcome

Non-invasive Brain Stimulation Paired with Robot-assisted Gait Training After Spinal Cord Injury

Chronic Rapamycin Administration After High-Thoracic Spinal Cord Injury Exacerbates Cardiovascular Dysfunction

Age Increases Reactive Oxygen Species Production in Macrophages and Potentiates Oxidative Damage After Spinal Cord Injury

Compression Decreases Anatomical and Functional Recovery and Alters Inflammation after Contusive Spinal Cord Injury

Mitochondrial Transplantation into the Injured Spinal Cord Improves Cellular Respiration

Flubendazole Improves Recovery Following Spinal Cord Injury in Rats

Optogenetic-induced Glutamate Release in the Rodent Hippocampus and Frontal

Sudden Unexpected Death in Epilepsy and Functional Remodeling of Vagal Complex Activity in a Mouse Model of Temporal Lobe Epilepsy

Lafora Epilepsy - Basic Mechanisms to Therapy

Precision Imaging and Histological Phenotyping for RNA Profiling of Human Epilepsy Tissue

• Tunable Somatosensory Stimulation for Selective Sleep Restriction Studies in Rodents
• Effect of Temperature on Sleep Regulation in an Animal Epilepsy Model
• A Mathematical Model of Ultradian Sleep-Wake Regulation in Rodents
• Effect of Vigilance State on the Spatial Profile of Cortical High Frequency Oscillations
• Autonomic Variables and their Correlation with Electrophysiological Markers in Epilepsy Patients Undergoing Phase II Presurgical Evaluation

• Correlating Common TDP-43 and Tau Pathologic Patterns in the Aged Human Hippocampus
• Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)-Based Identification of Neuronal Dysfunction Before the Appearance Tau Pathology in rTg4510 Mice
• Aβ Imaging Ligand Pittsburgh Compound B Binding in AD Frontal Cortical Synaptosomes is in Glutamatergic Synapses
• Declines in Default-mode Network Structure and Function Mediate the Negative Effects of Alzheimer's Pathology on Executive Function in Older Adults
• Clinical Impact of MRI-Evident, Deep vs Periventricular T2 Abnormalities on Cognitive Impairment in Cerebrovascular Disease and Other Leukopathologies
• A Multiple Ascending Dose Study of HDAC Inhibition for Modulation of Apoj/Clusterin Risk in Alzheimer's Disease
• Acute Insulin Treatment of Hippocampal Neurons Highlights New Mechanisms of Action
• Indentification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brains
• Aged Animals Appear Cognitively and Behaviorally Hyporesponsive to Chronic Restraint (Psychosocial Stress) Compared to Young Animals
• Selective Modulation of Neuroinflammation by Targeting p38α MAPK with a Novel, Isoform-specific Inhibitor, MW150, in an Alzheimer's Disease Mouse Mode
• The Role of Autophagy and the UPR in the Development of Alzheimer Disease in a Mouse Model of Down Syndrome Neuropathology
• The Anti-NPI: A Novel Tool for Assessment of Neuropsychiatric Symptoms in Clinical Trials for Prodromal Alzheimer's Disease

• Using a Modified Cannula Delivery System to Implant Sural Nerve Grafts into the Rhesus Macaque Midbrain
• Pathological Findings from Two Parkinson Disease Patients After Intraputaminal GDNF Infusion
• Non-invasive Delivery of an Amidated Neuroactive Peptide in Models of Parkinson's Disease
• Distinct Synuclein Seeds in Parkinson Disease and Multiple System Atrophy
• Combining Cell Therapy with Deep Brain Stimulation for the Treatment of Parkinson's Disease
• Deep Brain Stimulator Implantation Under General Anesthesia

• Intraneuronal Amylin Disposition, Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of AD Patients with T2D and Diabetic HIP Rats
• Microglia Heterogeneity in the Hippocampus of Alzheimer's Disease, Dementia with Lewy bodies, and Hippocampal Sclerosis of Aging
• Addressing Innovation in CNS Drug Discovery: Functional or Single Molecular Target Approaches to Novel Compounds that Attenuate Synaptic Dysfunction
• TREM-2 Induced Microglial Activation Promotes the Clearance of Amyloid-beta in an AD Mouse Model
• Cognition and Affect in Possible Serial Autoimmune Episodes of Anti-NMDA-Receptor Encephalitis
• Targeting Neuroinflammation in Vascular Cognitive Impairment with a Novel, CNS-Penetrant, Small Molecule Experimental Therapeutic
• Therapeutic Approaches to Target Inflammation Following TBI Through Inhibition of the p38α MAPK

• Novel Synthetic Isoflavanoid for the Treatment of Alcohol and Nicotine Co-use
• Discovery of Vesicular Monoamine Transporter-2 Inhibitors as Potential Treatment for Methamphetamine Abuse: N-Butyl(1-methyl-2-phenylethyl)amine isome
• Identifying Organelle Specific Intracellular Changes in Nicotinic Acetylcholine Receptors in Response to Ligand Exposure Using Fluorescence Microscopy
• JPC-077 Interacts with VMAT2 to Decrease the Neurochemical and Behavioral Effects of Methamphetamine
• Directed Evolution of Terpene Synthases to Alter Product Specificity Towards Compounds with Anxiolytic Properties

• RIT1 is Required for IGF1-mediated Neurogenesis
• An Examination of Corticomotor Plasticity in Individuals with and without Chronic Ankle Instability
• Diabetes-induced Changes in Brainstem GCK Expression
• Signaling and Expression of a Truncated, Constitutively Active Human Insulin Register
• DREADD(ed) Evidence for Modulation of Blood (glucose) by the Dorsal Hindbrain

• Early Tracheostomy and Percutaneous Endoscopic Gastrostomy in Hemorrhagic Stroke Patients: Associated Factors and Effects on Hospitalization
• Nerve Stimulation Paired with Task-Oriented Training Improves Chronic, Severe Hemiparesis After Stroke: A Randomized Trial
• Closed Loop Afferent Electrical Stimulation for Recovery of Hand Function in Individuals with Motor Incomplete Spinal Injury: Early Clinical Results
• Kentucky Care Coordination for Community Transitions (KC3T)
• An Electromyography Study of Muscular Endurance during the Posterior Shoulder Endurance Test
• Physician and Physical Therapist Communication is Associated with Earlier Mobility and Decreased Length of Stay in the Neuroscience Population
• Optimizing Transcranial Direct Current Stimulation for Motor Recovery from Sever Post-stroke Hemiparesis

• Fingolimod Ameliorates Central Neuropathic Pain
• The Spinal Effects of the VGF-derived Peptide TLQP-21 are Mediated by the Complement 3a Receptor
• Latent Sensitization is Masked by Spinal Mu and Kappa, but not Delta Opioid Receptor Analgesia in a Preclinical Model of Postoperative Pain
• 15-Deoxy-Delta-12,14-prostaglandin J2 Activates Peripheral Peroxisome Proliferator-activated Receptor Gamma Gamma and Opioids Receptors to Reduce Inflammatory Muscle Pain
• Sex Differences in the Therapeutic Effects of Pioglitazone on Type II Painful Diabetic Neuropathy
• Cannabinoid Receptor 2 Agonist Attenuates Pain Related Behavior in Rats with Chronic Alcohol/High Fat Diet Induced Pancreatitis

• Research Plan for a Case Report of D-Lyxo-Hexulose Treatment in an Infant with Prader-Willi Syndrome
• Utility of the CAARS Validity Scales in Idnetifying Feigned ADHD, Random Responding, and Genuine ADHD
• A Prospective Evaluation of Swallowing and Speech in Patients with Neurofibromatosis Type 2
• Acetyl-L-carnitine Attentuates Hypersensitivity in an Alcohol/high-fat Diet Induced Rat Chronic Pancreatitis Model
• Dual PI3K/Akt Inhibition: A New Strategy to Improve Drug Delivery in Glioblastoma Therapy
• Cardiorespiratory Fitness is Associated with Executive Function in Older Adults