Facilities
DLAR consists of 6 main facilities, with the Medical Center consisting of the Main (Animal) facility and 6 smaller centers and suites.
Environmental and Husbandry Standards Maintained in DLAR Facilities (for ARRIVE Guideline use)
The Medical Center
The Medical Center consists of the Main (Animal) Facility, the Dental Wing, the Combs Cancer (Animal) Center, the Central Animal Facility (CAF), and the NHP facility, Experimental Surgery Suite and Sheep Surgical Suite.
The Main (Animal) Facility, Dental Wing, Combs and the Central Animal Facility are conventionally designed. The facility contains over 50 animal housing rooms totaling 16412 ft2 and support space of 23458 ft2. The facility has conventional, barrier and BSL2 housing capabilities.
Access is controlled via card swipe and iris scan. In order to access the entrances (HSRB, Main and Combs) each person must have a UK ID badge and be enrolled in the EyeLock system. Access is granted to research staff who are on an active protocol and have animals housed in one of the facilities listed above.
The Sanders Brown Embryo Cryopreservation and Rederivation Core Facility (ECRC)
The Sanders Brown Embryo Cryopreservation and Rederivation Core Facility (ECRC) is located on the fourth floor of the Sanders Brown Center for Aging Building. There is a total 5,078 ft2, divided among 5 animal housing rooms, laboratory spaces, support functions and corridors.
The facility operates on a clean/dirty corridor system for all housing rooms except the quarantine holding room. All equipment entering the rederivation barrier rooms is sterilized and all personnel shower and don dedicated clothing.
Movement of animals from the ECRC to research laboratories is unidirectional. Animals entering the ECRC rederivation barrier enter via embryo transfer rederivation. Redervied mouse strains are initially expanded in the ECRC barrier before distribution to the investigators.
ECRC access is controlled via Medical Center identification badges and PINs coded for card readers at three entrances. Permission for key or card access is under the jurisdiction of the Director, DLAR. There are cameras for each entrance and in the corridors.
The Biomedical and Biological Sciences Research Animal Facility
The Biomedical and Biological Sciences Research Animal Facility is located on the basement level of this four story research building. The facility is contiguous in layout and functions as a single operational unit. The facility contains 23 animal housing rooms totaling 7,093 ft2 and support space of 14,035 ft2 which includes 2475 ft2 procedure & surgery. The facility is conventional in design.
The facility is contiguous in layout and functions as a single operational unit. The facility contains 23 animal housing rooms totaling 7,093 ft2 and support space of 14,035 ft2 which includes 2475 ft2 procedure & surgery.
The facility contains a total of nine animal procedure rooms, a sterile rodent surgical suite, and a necropsy/perfusion room. These rooms are available on a shared and or reservation system to investigators.
Movement of animals outside of the animal facility to laboratories in the BBSRB is restricted. Exceptions to this rule are reviewed by DLAR and the IACUC with permission granted for procedures where the requirement for specialized instrumentation or time critical processing of harvested tissues can be documented.
Building and animal facility access to the Biomedical and Biological Sciences Research Building is controlled via Medical Center identification badges coded for card readers. All animal housing rooms in the animal facility have room level security provided by the Edstrom Watchdog® System and a unique PIN is assigned to users to access individual animal housing rooms.
The Multi-disciplinary Science Building Facility
The Multi-disciplinary Science Building Facility (5,844 ft2) is located on the first floor of the Multi-disciplinary Science Building, which is approximately 200 yards from the Medical Center complex.
The facility is designed with a clean/dirty corridor, but it is operated conventionally.
The Biological Pharmaceutical Complex Animal Facility (Lee Todd Building)
The Biological Pharmaceutical Complex Animal Facility (Lee Todd Building) is located on the basement level of this five story research building. The facility is contiguous in layout and functions as a single operational unit. The facility contains 13 animal housing rooms totaling 6,319 ft2 and support space of 12,543 ft2 which includes 1,256 ft2 of surgery space.
The facility is conventional in design. The facility contains a total of 13 animal procedure rooms, two sterile rodent surgical suites, and a necropsy/perfusion room. These rooms are available on a shared and or reservation system to investigators. There are also seven designated behavioral rooms, five of which are located within the same corridor. The remaining two are located off the main corridor.
Movement of animals outside of the animal facility to laboratories is strictly limited. Exceptions to this rule are reviewed by DLAR and the IACUC with permission granted for procedures where the requirement for specialized instrumentation or time critical processing of harvested tissues can be documented.
Animal facility access for the Biological Pharmaceutical Animal Facility is both a card reader and PIN access and card reader exit. Building and animal room access is controlled via Medical Center identification badges coded for card readers. There are cameras in the main corridors.
The Spindletop Facility
The Spindletop Facility (7,458 ft2) is located on a 20-acre plot, 10 miles north of the University of Kentucky, Chandler Medical Center, within the University’s North Farm complex.
The facility is conventional in design. Permanent canine caging (with outdoor runs) is located in this facility Rooms 12, 13, and 15 have been designated as Animal Biosafety Level-2 and are used for non-approved vendor rodent quarantine if needed.
No dedicated research laboratories are located within this facility. Animal procedure rooms and research laboratories are set up to accommodate the various research projects on an as needed basis.
This large farm complex is routinely patrolled by University security personnel. Access to any of the farm areas is limited (gates w/card access) during the evening hours and on weekends. Entrance to the Spindletop Animal Facility is through a key-controlled entrance door that remains locked at all times.