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Institutional Animal Care and Use Committee

IACUC Policies, Procedures, and Guidelines

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Doc 100 - "Guidance on Protocol Submission Deadlines"

Doc 101 - "Definition of Animal and Approved Animal Numbers"

(Updated 01/2026) Doc 102 - "Surgery"

Doc 103 - "Euthanasia"

Doc 104 - "Anesthesia Equipment"

(Updated 3/2026) Doc 105 - "Housing Animals Outside of DLAR Facilities"

Doc 106 - "Training and Continuing Education Requirements"

Doc 108 - "Documentation of IACUC Activities"

Doc 109 - "Humane Use Pain Classifications (Pain Categories)"

Doc 110 - "Housing Density"

Doc 112 - "Animal Care and Use Protocol Review Process"

(Updated 02/2026) Doc 113 - "Requirements for PI on IACUC Protocols"

Doc 114 - "UK/VA Joint Protocols"

Doc 115 - "Procedure for Conducting IACUC Business During a Pandemic"

Doc 116 - "Research Surgical and Procedural Records"

Doc 119 - "Use of Non-Pharmaceutical Grade Compounds"

Doc 123 - "Off-Site Animal Use"

Doc 124 - "Semiannual Site Inspections"

Doc 128 - "Investigation of Reported Alleged Deviations"

Doc 129 - "Social Housing and Environmental Enrichment"

Doc 130 - "Training Requirements for Animal Care Personnel Performing Research Activities"

Doc 131 - "Adoption Policy"

Doc 132 - "Pilot Studies"

(Updated 02/2026) Doc 133 - "Animal Transport"

Doc 134 - "Expired Medical Materials"

Doc 135 - "Policy on Labeling and Dating of Compounded Pharmaceuticals"

Doc 136 - "Policy on Rodent Tumors"

Doc 137 - "Equipment Disinfection"

(Updated 02/2026) Doc 138 - "Contracted or Subcontracted Animal Activities"

Doc 139 - "Weight Loss and Body Condition Score"

Doc 140 - "Prolonged Physical Restraint"

Doc 141 - "Food and Fluid Restriction for Experimental Purposes"

Doc 142 - "AV Oversight of the Program of Veterinary Care"

(NEW 4/2026) Doc 143 - "IACUC Approved Surgical Procedures"

Guidance and Support Documents

Guidance on Protocol Submission Deadlines
(pdf, 1 pg)
Additional Definitions for Policy 101 Approved Animal Numbers
(pdf, 2 pgs)
Guidelines for Meeting Policy 102 Surgery Requirements
(pdf, 10 pgs)
Guidelines for Euthanasia of Research Animals
(pdf, 4 pgs)
Diagnostic Necropsy Guidelines
(pdf, 4 pgs)
Large Animal Anesthesia and Analgesia
(pdf, 12 pgs)
UK Research Guide for DEA Controlled Substances
(pdf, 47 pgs)
Congruency Requirements for Vertebrate Animal Activities Funded by PHS or NSF
(pdf, 2 pgs)
Guidelines for Testing of Biological Materials
(pdf, 2 pgs)

Regulatory References and Resources

University of Kentucky AR 7:5 (Institutional Program for Animal Care and Use)

The Guide (8th Edition, 2011)
(pdf, 246 pgs)

The Ag Guide (4th Edition, 2020)
(pdf, 227 pgs)

Health Research Extension Act of 1985

PHS Policy
(pdf, 28 pgs)

U.S. Government Principles

AVMA Guidelines for the Euthanasia of Animals: 2020 Edition
(pdf, 121 pgs)

Animal Welfare Act and Animal Welfare Regulations
(pdf, 352 pgs)

USDA Animal Welfare Information Center (AWIC)

Canadian Council on Animal Care - Three Rs

National Centre for the Replacement, Refinement and Reduction of Animals in Research

American Fisheries Society - Guidelines for the Use of Fishes in Research
(pdf, 104 pgs)

American Society of Ichthyologists and Herpetologists - GUIDELINES FOR USE OF LIVE AMPHIBIANS AND REPTILES IN FIELD AND LABORATORY RESEARCH(pdf, 43 pgs)

The Ornithological Council - Guidelines to the Use of Wild Birds in Research
(pdf, 66 pgs)

Institutional Animal Care and Use Committee
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