Turning the Bedside into the Bench: Uncovering Ischemic Stroke Pathology

Objectives:

• Appreciate the importance of identifying key mechanisms and new potential drug targets in ischemic stroke.
• Understand the importance of extracellular vesicles, perfusion imaging, and information that can be gleaned from important biomarkers within.
• Develop an understanding of the need for new therapies and advanced imaging in ischemic stroke patients

The BACTRAC tissue bank was developed as a collaborative opportunity for basic, translational, and clinical researchers and surgeon-scientists. This endeavor fostered dozens of publications and has led to new grants and research avenues, including EV isolation/analysis, proteomics, and platelet biology. PRISM builds upon the BACTRAC foundation, leveraging real-time perfusion imaging during ischemic stroke paired with intracranial blood sampling to develop a better understanding of the ischemic stroke microenvironment and to identify new therapeutic targets to offset secondary injury in stroke patients.
      
Presenters:
Justin Fraser, MD, FAANS, FAHA, FCNS
Professor and Vice-Chair
Neurological Surgery
University of Kentucky
   
Amanda Trout, PhD
Assistant Professor
Department of Neurology
University of Pittsburgh
   
David Dornbos III, MD, FAANS, FCNS
Assistant Professor
Neurological Surgery
University of Kentucky
 

More information here.