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A new University of Kentucky College of Medicine study provides insight into how a protein called angiotensinogen (AGT) contributes to blood pressure regulation and atherosclerosis.

By means of open access, Progress in Scale Modeling stands out as a barrier-free venue to disseminate peer-reviewed research for the benefit of society, scholarship and humanity.

“We operate as a single team, combining our expertise in order to tackle the complex multi-physics problems that arise in astrophysics — problems that are beyond the capacity of a single investigator.”

The challenge, Moseley says, is in analyzing this complex data to derive new biological knowledge and in making this data and knowledge available in a highly reusable format in public scientific repositories.

Through the group's work, they found that the therapeutic targeting of TREM2 using a TREM2-activating antibody leads to the activation of microglia, recruitment of microglia to amyloid plaques, reduced amyloid deposition, and ultimately improved cognition.

“We used to think that aging-related memory and thinking decline meant one thing: a disease called Alzheimer’s disease. Now we know that the disease we were calling Alzheimer’s disease is actually many different conditions, often in combination."

"When I came to the U.S. and was confronted with the health care system here, I wasn’t comfortable practicing medicine without doing something to serve people who don’t have proper access to care because they’re uninsured or far from services."

The team suggests a number of changes to help rebuild trust and reduce stigma for opioid use disorder in rural communities; they also suggest that wholesalers change algorithms to track buprenorphine separately from other opioids.

Coal-to-carbon fiber research shows great promise to positively impact the nation’s sluggish coal industry. In 2019, U.S. coal production, consumption and employment reached their lowest levels in 40 years.

ARD is an annual event hosted by the University of Kentucky Center of Excellence in Rural Health (CEHR) to share results of health research conducted with communities in Appalachia.